BIOMED REPORT
with Grover disease
The American
Academy of
Dermatology
(DAAD):
Credit:
JAAD :
Birthday:
12/26/1920 - Death:
5/25/2008:
Ralph Grover
has passed away,
we regret
to report;
date of death
was
05/25/2008,
Ralph was
87 years old
at the time
WHO HAS
A DIAGNOSIS OF
GROVER'S DISEASE?
At the Cross Roads of Skin Diseases
May 14, 2019
Yiu are right, when you say, you don't know anything about this so-called pruritic, papulovesicular dermatosis as a disease for the skin of the white, middle aged men. It is known as Grover's disease (GD) in the public.
A medical website in the Internet "Webmed.com" writes about rashes in the skin with the following words, "A rash indicates an abnormal change in skin color or texture. Rashes are usually with a relation to GROVER' S DISEASE require the experts whose pathological and histological examination in the skin biopsies make clear the evidences for this nonhereditary vesicobullous disorder in the patients.
Many skin experts (Dermatologists) like Joshua Weaver and Wilma F. Bergfeld, in their published article "Grover Disease (Transient Acantholytic Dermatosis" (September 2009) write this: "Grover disease's pathogenesis still remains unknown."
Grover Disease (Transient Acantholytic Dermatosis)
Those men who are older than 5o years old and experience the skin rashes on their bodies decide to go to a dermatologist for a correct diagnosis. A dermatologist after an examination of their skin rashes prescribes a drug for 2 weeks with a brand name "Betaderm" whose common name is "Betamethasone valerate." The doctor suggests to this patient to use this drug for only 2 weeks. The 3rd week not using this drug.
Then, after 3 weeks, the patient will return to his/her dermatologists for the next step of histological examination and findings in skin biopsies which will be taken from their affected skins.
A website in the Internet "Uniprix.com" writes the following: "Betamethasone valerate belongs to the class of medications called topical corticosteroids. It is used to treat skin irritation and itch caused by skin conditions such as eczema, psoriasis, contact dermatitis, and seborrhea. It works by reducing redness, inflammation, swelling, and irritation of the skin."
Source:
Betaderm
The website "webmed.com" says, " Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid."
Source:
"Webmed.com":
Betamethasone Valerate
Ointment
the affected skin.
Joe McDonald in his BlogSpot with a titled "McDonald Diagnosed With Grover's Disease" writes the following words, "A routine annual skin examination yielded a surprising diagnosis Friday, when Joe McDonald was diagnosed with Grover's Disease.The disease contains several stages and its progression varies by the patient, Dr. Wisdom explained."
Source:
Joe McDonald's Hidden Blog
This blogger, J. McDonald, who has been diagnosed with the Grover disease adds, "In stage 1, the skin experiences eraser-sized dots sensitive to heat and moisture which are prone to occasional itchiness. The skin may or may not respond to treatments such as a steroid-based cream."
The writer of this information goes on to say, "While it seldom progresses past the first stage, advanced cases of the condition exhibit prevalent thick blue patches of fur, bulbous unblinking eyes, ballooned pink nose and emaciated arms."
This blogger who has been diagnosed with this skin disease further explains, "End-stage Grover's sufferers normally develop lips that are extraordinarily thin, wide, and red, with no discernible beginning or end. Despite loss of tongue and the inability to maneuver the lips to form letters other than random flapping of the lower jaw, speech is remarkably unimpaired, although voice pitch typically becomes more gravelly and cute."
Source:
Joe McDonald's Hidden Blog
The dermatologists like Joshua Weaver, MD and Wilma F. Bergfeld, MD, who published their article about Grover Disease in Archives of Pathology & Laboratory Medicine: September 2009 [ Vol. 133, No. 9] in which they note, "After the original description of Grover disease, Grover and Rosenbaum discovered a clinically significant association between Grover disease and other dermatitites."
Source: Grover, R. W. and R. Rosenbaum . The association of transient acantholytic dermatosis
with other skin diseases. J Am Acad Dermatol 1984. 11:253–256
The experts like Desch, J. K. and B. R. Smoller in their article "The spectrum of cutaneous disease in leukemias" published in J Cutan Pathol 1993 [20:407–410] concluded: "Cancer, including acute leukemia, was soon linked with Grover disease."
Desch, J. K. and B. R. Smoller . The spectrum of cutaneous disease
in leukemias. J Cutan Pathol 1993. 20:407–410.
Drs Weaver and Bergfeld, the dermatologists, in their published article address that Grover disease is the prototypic presentation of Grover disease consists of a self-limited papulovesicular rash on the upper trunk of an older white male."
These experts also add, "Because Grover disease has been associated with so many inflammatory and neoplastic conditions, it is important to examine each biopsy for additional diagnoses, especially concurrent hematologic malignancies, including leukemias, which may alert clinicians of progressing disease."
Source:
Grover Disease (Transient Acantholytic Dermatosis)
Joshua Weaver, MD;
Wilma F. Bergfeld, MD:
Grover Disease
(Transient Acantholytic Dermatosis)
On Wed 30 May 2018, in the website "medicalnewstoday.com" Scott Harris in an article entitled "Grover's disease: What you need to know" writes the following, "Grover's disease is an uncommon but potentially debilitating skin condition. Doctors are not yet sure what causes the disease or how to cure it, but treatments are available to manage the symptoms."
Source:
Grover's disease:
What you need to know
The author of the article, Mr. Harris goes on to say, "Also called transient acantholytic dermatosis, Grover's disease typically presents as a rash on the chest and back. Intense itching often accompanies the rash."
The writer talks about treatment of Grover's disease: "Possible treatments include oral medications and topical creams for direct application to the skin. The most effective treatment will vary from person to person, so people with Grover's disease will need to consult with a doctor to find what works best for them."
Source:
Grover's disease:
What you need to know
This article written by Mr. Harris address the following points, "Grover's disease usually begins as small itchy red bumps on the back and chest, which may then spread to the upper limbs.The bumps are usually slightly raised but can feel soft or hard to the touch. Water-filled blisters may appear alongside or inside these bumps."
The published of the article explains some more details, "According to some sources, Grover's disease primarily affects white men aged 50 and above and is less common in women and younger people. It is very rare, with a Swiss study finding only 24 (0.08 percent) examples of Grover's disease among 30,000 skin biopsies."
Source:
Grover's disease:
What you need to know
Jonathan L, Held, M.D., DavM Bank, M.D.,and Marc E. Grossman, M.D,Columbia Presbyterian Medical Center, New York, NY 10034 write to the editor of The Journal of the American Academy of Dermatology (JAAD) (Volume 19, Number 1, July 1988) the following points about Grover's disease provoked by ionizing radiation: "Grover's disease or transient acantholytic dermatosis, first described in 1970,' is an eruption of papules or papulovesicles that usually occurs on the trunk of adults. We report the first case of Grover's disease precipitated by ionizing radiation."
The authors add, "Biopsy reveals focal changes resembling either Darier-White disease, Halley-Halley disease, pemphigus, or spongiotic dermatosis.[Chalet M, Grover RW, Ackerman AB. Transient acantholytic dermatosis: a reevaluation. Arch Dermatol 1977;113:431-5.].
Source:
Grover's disease provoked by ionizing radiation
Wikipedia writes, " Once Grover's disease (GD) confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis.
This website, Wikipedia says, "Grover's disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress.
Source:
Wikipedia:
Transient acantholytic dermatosis
National Organization for Rare Disorders (NORD) in its website "rarediseases.org" writes, "Grover's disease is a rare, transient skin disorder that consists of small, firm, raised red lesions, most often on the skin of the chest and back. Diagnosis of this disorder becomes apparent under microscopic examination when the loss of the "cement" that holds the skin cells together is observed."
Source:
NORD:
Grover’s Disease
The NORD's website adds, " Symptoms of Grover’s disease are small, solid, raised bumps on the skin; separation of connective tissue in the skin’s outer layers (acantholysis); and itching (pruritus)."
The same source address, "Over time, as the skin loses the "cement", the cells separate (lysis). Small blisters containing a watery liquid are present. These blisters tend to group and have a swollen red border around them... For some patients the itching may be severe. Patients with this disorder often have blisters containing a thin, watery liquid with hair follicles (recessed spots with a central hair) within the affected area."
It goes on to say, "Grover's disease is mainly seen in males older than forty or fifty. Its cause is unknown but it is thought to be related to trauma to sun damaged skin."
This website for rare diseases points out that the exact cause of Grover’s disease is not known. It may be related to fragility of old sun-damaged skin. Some doctors feel that this skin disorder may be related to heat and sweating." The site says, "At least one case of this disorder has been associated with follicle mites which are parasites."
Source:
NORD:
Grover’s Disease
GROVER's Disease, GD
بیماری گراور
یا
Grover’s disease که به آن
درماتوز
آکانتولیتیک گذرا
نیز می گویند,
یک بیماری
مزمن
و آزاردهنده
است
اما اصلا
جدی نیست
و خود به خود
خوب می شود.
متاسفانه
درمان قطعی
برای آن
وجود ندارد.
Could
human polyomaviruses
cause
grover disease?
Случай транзиторного акантолитического
дерматоза Гровера у женщины
Болезнь Гровера
(преходящий акантолитический дерматоз)
Болезнь Гровера:
причины
заболевания,
основные
симптомы,
лечение и
профилактика
TRANSIENT
ACANTHOLYTIC DERMATOSIS
GROVER'S DISEASE
A FORM OF SKIN DISEASE
May 06, 2019
The word ACANTHOLYSIS as the primary pathological change in the skin, may appear as a complex term which cause perplexity, but in the field of dermatology, the experts find the ways to describe it with very simple words.
In 2017, Ann M. Hargis, Sherry Myers, in Pathologic Basis of Veterinary Disease (Sixth Edition) write, "Acantholysis is the disruption of intercellular junctions (desmosomes) between keratinocytes of the epidermis." [1]
The authors of this article, Hargis and Myers add, "The process is initiated by damage to transmembrane glycoproteins belonging to the cadherin family of adhesion molecules and leads to splitting of the extracellular core of the desmosomes. Subsequently the desmosomal plaques dissolve, and intermediate filaments retract to the perinuclear region of the keratinocytes." [1]
On 1 August 2010, the site of "PATHOLOGY OUTLINES" describes acantholysis with the following words: "Acantholysis is the loss of intercellular connections (desmosomes) between keratinocytes; occurs in pemphigus vulgaris and related disorders; causes change in cell shape from polygonal to round. [2]
On March 2017, in the website of Kansas State Veterinary Diagnostic Laboratory, Dr. Chanran Ganta writes in his article dermatology focus about acantholysis. He describes it as weakening of the connections between the keratinocytes resulting inpustules that often contain free floating loose keratinocytes.[3]
A study published by Dr. Wilma Bergfeld is a dermatologist in Cleveland, Ohio and Dr. Jason Weaver is a dermatologist in Bryan, Texas in Archives of Pathology & Laboratory Medicine (issue of September 2009). The titled of study was "Grover disease (transient acantholytic dermatosis)".[4]
Authors of this study, Drs Bergfeld & Weaver note, "Grover disease, also known as transient acantholytic dermatosis, is a papulovesicular rash of the upper trunk, generally among older white males; it is usually pruritic but temporary." [4]
The writers add, "Grover disease is characterized by 4 different acantholytic histologic patterns, and it has been associated with numerous disorders, including hematologic malignancies." [4]
They go further to address, "Follow-up and treatment are often difficult to evaluate secondary to the spontaneous remittance and occasional fluctuant course of the disease." [4]
They say, "Our objective will be to discuss the diagnostic considerations of Grover disease and focus on the postulated pathogenesis, including concurrent disorders and the role of the pathologist in examining skin biopsies of this nonhereditary vesicobullous disorder." [4]
These dermatologists point out our objective will be to discuss the diagnostic considerations of Grover disease and focus on the postulated pathogenesis, including concurrent disorders and the role of the pathologist in examining skin biopsies of this nonhereditary vesicobullous disorder. Although recognized as a common condition, Grover disease's pathogenesis still remains unknown. [4]
Finally, they conclude, "Because Grover disease has been associated frequently with other dermatologic and nondermatologic skin conditions, inspection for other pathologic processes within the skin biopsy is essential to rule out other concomitant disorders, including hematopoietic malignancies."[4]
Dr. Ralph Wier Grover
Died on May 25, 2008
Dr. James M. Krivo:
" Everyone knew about the pet ducks that he kept in his yard."
Dr. A. Bernard Ackerman:
"To have been a solo practitioner of dermatology and to have identified a disease ‘‘missed’’ for centuries by ‘‘experts’’ in academe is no surprise to those
who knewthe brilliant turn of mind of Ralph."
Dr. James Krivo MD
Garden City, NY
Dermatology:
near Garden City,
NY
Dermatologists
in Franklin Square,
NY
In an article (In Memoriam: Dr. Ralph Wier Grover), James M. Krivo, A. Bernard Ackerman,and Marvin I. Lepaw, Valley Stream, New York, and Dix Hills, New York, write their information and experiences about the late Dr. Glover. [5]
Dr. James M. Krivo writes, "I have had the privilege of being one of the people
who has learned something about medicine and dermatology from Dr Ralph Grover. Ralph
passed way on May 25, 2008." [5]
The writer Dr. Krivo says, " [Dr Ralph Wier Grover] was a physician, a teacher, a researcher, a friend, a father, and a husband." [5]
Dr. Krivo in this article in memoriam adds, "His home office in Floral Park, NY was a place where residents, medical students, and interns in training would rotate to learn from a dedicated teacher, where he stored all the information needed the old-fashioned way, on little 436 cards filled with beautiful drawings, diagramming where and what lesions looked like." [5]
Dr. Krivo continues to address the following: "Going to his office was as much
like going to a relative’s home as a doctor’s office. Everyone knew about the pet ducks that he kept in his yard. And he spent time with his patientseas much as they needed." [5]
Dr. A. Bernard Ackerman writes in this article, "I had the great pleasure of working, in the mid-1970s, with Ralph Grover, the subject of our endeavor being variants histopathologic of ‘‘transient acantholytic dermatosis,’’ a condition first recognized and described by him, and that by the time we collaborated had already become known as Grover’s disease." [5]
Dr. Ackerman goes on to say, "To have been a solo practitioner of dermatology and to have identified a disease ‘‘missed’’ for centuries by ‘‘experts’’ in academe is no surprise to those
who knewthe brilliant turn of mind of Ralph." [5]
Dr. Ackerman's words provide the following information: " He [Dr. Ralph Wier Grover] was
an original in every respecteand a joy to work with. Not only did he have a marvelous, wry sense of humor, but he could be playfully puckish in selfdeprecation." [5]
Dr. Ackerman continues to address, "As but one example, his middle name was ‘‘Wier,’’ about which he commented to me, ‘‘they left off the ‘d’!’’ It is regrettable that Ralph Wier Grover
was not known personally to colleagues and trainees beyond Long Island. They would have reveled in his company and in his intellect, just as did I." [5]
Dr. Marvin Lepaw explain his experiences and feelings with the following words, "have had the extreme good fortune to have worked in Ralph W. Grover’s office from 1965 to 1970. He started the first dermatology clinic at Meadowbrook Hospital (now known as Nassau University Medical Center) when I was an intern there."[5]
Dr. Lepaw goes on to add, "During that internship and into my residency in internal medicine, inpatients with unusual or interesting skin problems were presented to him on a weekly basis at that clinic." [5]
According to him {Dr.Lepaw ], "He [Dr. Ralph W. Glover] was a fantastic dermatologic teacher,
diagnostician, and histopathologist." [5]
Dr. Lepaw recalls, "During the past 47 years he maintained a close relationship with many of us younger dermatologists and we are grateful for his lifelong contributions and devotion to our field. I will miss him as a teacher and a friend. "[5]
Grover’s Disease
A site named "goroversdiseasetreatment.com" writes the following about "ACANTHOLYSIS": "ACANTHOLYSIS is defined as the loss of coherence between epidermal cells due to the breakdown of intercellular bridges, called desmosomes." [1]
This site adds, "Acantholysis is classified as Primary or Secondary. Grover’s Disease belongs the primary acantholysis group along with: Haily-Haily disease (HHD)".[1]
It also notes about the characteristics of Grover’s Disease (GD): "Acantholysis is the primary pathological change occurring in pemphigus and its variants such as Grover’s disease." [1]
It talks about the appearance of Glover disease. It says, ""Appearance of GD Always small red eruptions, lesions, gashes which do not heal for long periods. In some cases these eruptions crust and then break out again." [1]
It continues, "The sensation is of the effected skin is similar to having a sunburn. The GD area is dry, feels like burning, even hot to the touch. Stinging, prickly, tingling sensations come and go, like bumping into a cactus."[1]
It goes on to say, "Grover’s Disease is a benign, non-contagious condition of unknown origin.
PATIENTS’
DESCRIPTION of
GROVER’s Disease
Болезнь Гровера
Болезнь Гровера
(преходящий
акантолитический
дерматоз)
Это заразно?
Болезнь Гровера.
Симптомы
и причины.
Directory of
Physicians (MD/DO)
Specialties /
Dermatology
James Michael Krivo, MD
Dermatology
Garden City,
NY
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پیدا
می کند)
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One Mommy: A Struggle for Hope with Pemphigus
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Pemfigus nedir?,
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